Laboratory Virpath

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Scientific and medical context of influenza virus:
Influenza viruses belong to the Orthomyxoviridae family and are grouped into three types (A, B and C). These are enveloped viruses whose genome is presented in the form of eight single-stranded RNA segments of negative polarity. The type A viruses were isolated from humans and several animal species, including birds, while influenza B and C are virtually isolated than in men. Only type A viruses have pandemic potential. They are divided into subtypes which are classified based on antigenic specificities of the two surface glycoproteins: hemagglutinin (HA 1 to 16) and neuraminidase (NA 1-9).
Influenza is a viral infection caused by influenza virus type A and B that cause an epidemic every winter responsible for 1 to 8 million cases. As in many countries, the epidemic outbreaks have a significant impact in terms of mortality and morbidity; average lethality of an influenza epidemic is of the order of 0.1%.
Influenza viruses are pathogens whose mechanisms of replicative cycle are still a number of gray areas. While basic and clinical knowledge of these viruses are increasingly rich and complex determinants of pathogenicity, the nature of the immune response post-infectious and post-vaccination and the viral elements participating in the cooperative virus-bacterium are still only partially understood.Similarly, although the viral replicative cycle occurs in the nuclei of infected cells, the fine regulation of subcellular sites and mechanisms of viral replication and transcription remain to be characterized.
Furthermore, influenza viruses are constantly re-emergence by definition. This reflects their ability to brew genetic material between viruses of subtypes same or different, of human origin and / or animal. These exchanges of genes sometimes lead to the emergence of a new subtype adapted to humans which can lead to a pandemic. The mechanisms of appearance of these viruses and the molecular determinants that control cellular and viral genetic reassortment are not yet fully identified.
The fight against the flu based on two pillars: the approach prophylaxique, thanks to vaccination, and the therapeutic approach through the development of antivirals.These two fields of research are yet to expand, to enhance the immune response following vaccination, or to strengthen and enrich the therapeutic arsenal that can provide a better fight against these viruses.
In this context and biomedical science, the laboratory is organized into two teams thatfocus their activities in basic and applied research in the following areas:
Lina TeamViral Pathogenesis (Team LeaderProfessor Bruno Lina).
Vircell Team: Molecular determinants and viral functional interactions with the host cell (Team LeaderDr. Manuel Rosa-Calatrava).

                       Theme 1Study of the mechanisms of selective incorporation of viral genome into particles and characterization of interaction networks between specificgene segments.
                       Theme 2: functional interactions between influenza virus and certainsignaling pathways and cellular metabolic.